Symbol
Name
ID

Ptpn22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
MGI:107170

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Abnormal bleeding

Epistaxis

Hemolytic anemia

Leukopenia

Hemophagocytosis

Chronic lymphatic leukemia

Arterial thrombosis

Superficial thrombophlebitis

Abnormality of thrombocytes

Thrombocytopenia

Elevated erythrocyte sedimentation rate

Hepatosplenomegaly

Disease(s) Associated with PTPN22

autoimmune thrombocytopenic purpura

Behcet's disease

chronic lymphocytic leukemia

graft-versus-host disease

rheumatoid arthritis

systemic lupus erythematosus

temporal arteritis

Mouse Phenotypes

decreased B cell apoptosis

increased B cell proliferation

increased T cell proliferation

abnormal thymus morphology

enlarged thymus

thymus hyperplasia

abnormal thymocyte activation

enlarged spleen

spleen hyperplasia

abnormal B cell differentiation

increased transitional stage T1 B cell number

abnormal T cell differentiation

abnormal double-positive T cell morphology

increased double-positive T cell number

increased dendritic cell number

abnormal B cell number

increased germinal center B cell number

decreased mature B cell number

decreased follicular B cell number

increased follicular B cell number

increased B cell number

abnormal T cell subpopulation ratio

abnormal T cell number

increased effector memory CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta memory T cell number

increased CD4-positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

increased memory T cell number

increased regulatory T cell number

increased T cell number

abnormal B cell morphology

abnormal T cell morphology

increased spleen germinal center number

increased spleen germinal center size

abnormal B cell physiology

abnormal B cell activation

increased IgE level

increased IgG1 level

increased IgG2a level

increased IgG3 level

increased IgM level

abnormal T cell physiology

abnormal T cell activation

Availability

Mouse Genotype

Ptpn22^tm1.1Draw/Ptpn22^tm1.1Draw

Ptpn22^tm1.1Kas/Ptpn22^tm1.1Kas

Ptpn22^tm1Achn/Ptpn22^tm1Achn

Ptpn22^tm2Achn/Ptpn22^tm2Achn

Ptpn22^tm1.1Draw/Ptpn22⁺

Gt(ROSA)26Sor^{tm1(Ptpn22*)Draw}/Gt(ROSA)26Sor⁺
Cd19^tm1(cre)Cgn/Cd19⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23